Sriram Chandrasekaran

Associate Professor, Biomedical Engineering, College of Engineering & Michigan Medicine

Sriram Chandrasekaran, PhD, is an Associate Professor, Biomedical Engineering, College of Engineering & Michigan Medicine

Dr. Chandrasekaran’s Systems Biology and Drug Discovery lab develops computer models to decipher how thousands of proteins work together to orchestrate complex processes like embryonic development or metabolism and how this complex network breaks down in diseases like cancer. They are developing software tools to design drug combinations with enhanced potency and reduced potential for developing resistance. Systems biology software tools developed by his lab are available at https://systemsbiologylab.org/software. He teaches the AI in BME (BME 487) course that introduces students to AI and machine-learning algorithms and their applications in BME.  Learn more at the course website: https://systemsbiologylab.org/ai-bme-syllabus

 

Research Overview: We develop computational algorithms that integrate omics measurements to create detailed genome-scale models of cellular networks. Some clinical applications of our algorithms include finding metabolic vulnerabilities in pathogens (M. tuberculosis) using PROM, and designing multi combination therapeutics for reducing antibiotic resistance using INDIGO.
Research Overview: We develop computational algorithms that integrate omics measurements to create detailed genome-scale models of cellular networks. Some clinical applications of our algorithms include finding metabolic vulnerabilities in pathogens (M. tuberculosis) using PROM, and designing multi combination therapeutics for reducing antibiotic resistance using INDIGO.

Accomplishments and Awards