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Harm Derksen

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Current research includes a project funded by Toyota that uses Markov Models and Machine Learning to predict heart arrhythmia, an NSF-funded project to detect Acute Respiratory Distress Syndrome (ARDS) from x-ray images and projects using tensor analysis on health care data (funded by the Department of Defense and National Science Foundation).

Yongsheng Bai

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Dr. Bai’s research interests lie in development and refinement of bioinformatics algorithms/software and databases on next-generation sequencing (NGS data), development of statistical model for solving biological problems, bioinformatics analysis of clinical data, as well as other topics including, but not limited to, uncovering disease genes and variants using informatics approaches, computational analysis of cis-regulation and comparative motif finding, large-scale genome annotation, comparative “omics”, and evolutionary genomics.

Nicholson Price

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I study how law shapes innovation in the life sciences, with a substantial focus on big data and artificial intelligence in medicine. I write about the intellectual property incentives and protections for data and AI algorithms, the privacy issues with wide-scale health- and health-related data collection, the medical malpractice implications of AI in medicine, and how FDA should regulate the use of medical AI.

Ho-Joon Lee

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Dr. Lee’s research in data science concerns biological questions in systems biology and network medicine by developing algorithms and models through a combination of statistical/machine learning, information theory, and network theory applied to multi-dimensional large-scale data. His projects have covered genomics, transcriptomics, proteomics, and metabolomics from yeast to mouse to human for integrative analysis of regulatory networks on multiple molecular levels, which also incorporates large-scale public databases such as GO for functional annotation, PDB for molecular structures, and PubChem and LINCS for drugs or small compounds. He previously carried out proteomics and metabolomics along with a computational derivation of dynamic protein complexes for IL-3 activation and cell cycle in murine pro-B cells (Lee et al., Cell Reports 2017), for which he developed integrative analytical tools using diverse approaches from machine learning and network theory. His ongoing interests in methodology include machine/deep learning and topological Kolmogorov-Sinai entropy-based network theory, which are applied to (1) multi-level dynamic regulatory networks in immune response, cell cycle, and cancer metabolism and (2) mass spectrometry-based omics data analysis.

Figure 1. Proteomics and metabolomics analysis of IL-3 activation and cell cycle (Lee et al., Cell Reports 2017). (A) Multi-omics abundance profiles of proteins, modules/complexes, intracellular metabolites, and extracellular metabolites over one cell cycle (from left to right columns) in response to IL-3 activation. Red for proteins/modules/intracellular metabolites up-regulation or extracellular metabolites release; Green for proteins/modules/intracellular metabolites down-regulation or extracellular metabolites uptake. (B) Functional module network identified from integrative analysis. Red nodes are proteins and white nodes are functional modules. Expression profile plots are shown for literature-validated functional modules. (C) Overall pathway map of IL-3 activation and cell cycle phenotypes. (D) IL-3 activation and cell cycle as a cancer model along with candidate protein and metabolite biomarkers. (E) Protein co-expression scale-free network. (F) Power-low degree distribution of the network E. (G) Protein entropy distribution by topological Kolmogorov-Sinai entropy calculated for the network E.

 

Derek Harmon

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My research focuses on the intended and unintended consequences of language in financial markets. I examine this relationship across a number of contexts, such as the Federal Reserve, initial public offerings, and mergers and acquisitions. More broadly, my work aims to develop new theoretical and methodological approaches to understand the role of language in society.

Romesh Saigal

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Professor Saigal has held faculty positions at the Haas School of Business, Berkeley and the department of Industrial Engineering and Management Sciences at Northwestern University, has been a researcher at the Bell Telephone Laboratories and numerous short term visiting positions. He currently teaches courses in Financial Engineering. In the recent past he taught courses in optimization, and Management Science. His current research involves data based studies of operational problems in the areas of Finance, Transportation, Renewable Energy and Healthcare, with an emphasis on the management and pricing of risks. This involves the use of data analytics, optimization, stochastic processes and financial engineering tools. His earlier research involved theoretical investigation into interior point methods, large scale optimization and software development for mathematical programming. He is an author of two books on optimization and large set of publications in top refereed journals. He has been an associate editor of Management Science and is a member of SIAM, AMS and AAAS. He has served as the Director of the interdisciplinary Financial Engineering Program and as the Director of Interdisciplinary Professional Programs (now Integrative Design + Systems) at the College of Engineering.

Peter Adriaens

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My research focus is on the development and application of machine learning tools to large scale financial and unstructured (textual) data to extract, quantify and predict risk profiles and investment grade rating of private and public companies.  Example datasets include social media and financial aggregators such as Bloomberg, Pitchbook, and Privco.

Emily Mower Provost

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Research in the CHAI lab focuses on emotion modeling (classification and perception) and assistive technology (bipolar disorder and aphasia).

Behavioral Signal Processing Approach to Modeling Human-centered Data

Behavioral Signal Processing Approach to Modeling Human-centered Data