Tejaswi Worlikar

My research interests involve the development of histotripsy for clinical applications, which includes investigating how histotripsy impacts cancer progression and the immune microenvironment. Histotripsy is a non-invasive ultrasound (US) ablation technique that uses cavitation to mechanically disrupt the target tissue with millimeter accuracy.
I have significant experience with pre-clinical work, especially in histotripsy liver tumor treatment, developing animal models, performing animal surgeries, using ultrasound and MRI imaging for tumor monitoring, and programming code for histotripsy treatment planning. I am interested in building histotripsy imaging dataset (including post-ablation US and MRI, and follow-up imaging) using small animal models, and using machine learning and AI image segmentation algorithms to determine ablation efficacy by (characterizing the level of cellular disruption and identifying residual tumor) for improving treatment outcomes.