Our laboratory focuses on (1) the biology of cancer metastasis, especially bone metastasis, including the role of the host microenvironment; and (2) mechanisms of chemoresistance. We explore for genes that regulate metastasis and the interaction between the host microenvironment and cancer cells. We are performing single cell multiomics and spatial analysis to enable us to identify rare cell populations and promote precision medicine. Our research methodology uses a combination of molecular, cellular, and animal studies. The majority of our work is highly translational to provide clinical relevance to our work. In terms of data science, we collaborate on applications of both established and novel methodologies to analyze high dimensional; deconvolution of high dimensional data into a cellular and tissue context; spatial mapping of multiomic data; and heterogenous data integration.