The Frontiers in Data Science and Computing workshop brings together visionaries, scientists, practitioners and other stakeholders in computational science that includes both algorithmic aspects of data science and scientific computing. Our model for the Frontiers workshop series is based on the successful format commonly seen in Silicon Valley, which combines “big picture” motivation talks with activities designed to foster ideas, create communities, and allow significant interactions between application/domain scientists, algorithm designers and end users. Based on the successful outcomes of our pilot Frontiers workshop in 2015, we anticipate that this annual workshop series will result in fruitful scientific exchanges and new interdisciplinary collaborations across academia, industry and government agencies. In 2016, the Frontiers workshop will focus on data-infused computing, which is a new area that merges data science with scientific computing. “Frontiers in Data Science and Computing 2016” will be one of the first venues to explore this topic and its high-impact potential in areas as diverse as medicine, astronomy, physics, biology, computer architecture, smart grids, and climate change.