I build data science tools to address challenges in medicine and clinical care. Specifically, I apply signal processing, image processing and machine learning techniques, including deep convolutional and recurrent neural networks and natural language processing, to aid diagnosis, prognosis and treatment of patients with acute and chronic conditions. In addition, I conduct research on novel approaches to represent clinical data and combine supervised and unsupervised methods to improve model performance and reduce the labeling burden. Another active area of my research is design, implementation and utilization of novel wearable devices for non-invasive patient monitoring in hospital and at home. This includes integration of the information that is measured by wearables with the data available in the electronic health records, including medical codes, waveforms and images, among others. Another area of my research involves linear, non-linear and discrete optimization and queuing theory to build new solutions for healthcare logistic planning, including stochastic approximation methods to model complex systems such as dispatch policies for emergency systems with multi-server dispatches, variable server load, multiple priority levels, etc.
Prof. Huang is specialized in satellite remote sensing, atmospheric radiation, and climate modeling. Optimization, pattern analysis, and dimensional reduction are extensively used in his research for explaining observed spectrally resolved infrared spectra, estimating geophysical parameters from such hyperspectral observations, and deducing human influence on the climate in the presence of natural variability of the climate system. His group has also developed a deep-learning model to make a data-driven solar forecast model for use in the renewable energy sector.
Andrew uses mathematical and statistical modeling to address public health problems. As a mathematical epidemiologist, he works on a wide range of topics (mostly related to infectious diseases and cancer prevention and survival) using an array of computational and statistical tools, including mechanistic differential equations and multistate stochastic processes. Rigorous consideration of parameter identifiability, parameter estimation, and uncertainty quantification are underlying themes in Andrew’s work.
My broad research interests are in multi-agent systems, computational economics and finance, and artificial intelligence. I apply techniques from algorithmic game theory, statistical machine learning, decision theory, etc. to a variety of problems at the intersection of the computational and social sciences. A major focus of my research has been the design and analysis of market-making algorithms for financial markets and, in particular, prediction markets — incentive-based mechanisms for aggregating data in the form of private beliefs about uncertain events (e.g. the outcome of an election) distributed among strategic agents. I use both analytical and simulation-based methods to investigate the impact of factors such as wealth, risk attitude, manipulative behavior, etc. on information aggregation in market ecosystems. Another line of work I am pursuing involves algorithms for allocating resources based on preference data collected from potential recipients, satisfying efficiency, fairness, and diversity criteria; my joint work on ethnicity quotas in Singapore public housing allocation deserves special mention in this vein. More recently, I have got involved in research on empirical game-theoretic analysis, a family of methods for building tractable models of complex, procedurally defined games from empirical/simulated payoff data and using them to reason about game outcomes.
Catherine H. Hausman is an Associate Professor in the School of Public Policy and a Research Associate at the National Bureau of Economic Research. She uses causal inference, related statistical methods, and microeconomic modeling to answer questions at the intersection of energy markets, environmental quality, climate change, and public policy.
Recent projects have looked at inequality and environmental quality, the natural gas sector’s role in methane leaks, the impact of climate change on the electricity grid, and the effects of nuclear power plant closures. Her research has appeared in the American Economic Journal: Applied Economics, the American Economic Journal: Economic Policy, the Brookings Papers on Economic Activity, and the Proceedings of the National Academy of Sciences.
Biodiversity in nature can be puzzlingly high in the light of competition between species, which arguably should eventually result in a single winner. The coexistence mechanisms that allow for this biodiversity shape the dynamics of communities and ecosystems. My research focuses on understanding the mechanisms of competitive coexistence, how competition influences community structure and diversity, and what insights observed patterns of community structure might provide about competitive coexistence.
I am interested in the use and development of data science approaches to draw insights regarding coexistence mechanisms from the structural patterns of ecological communities with respect to species’ functional traits, relative abundance, spatial distribution, and phylogenetic relatedness, through as community dynamics proceed. I am also interested in the use of Maximum Likelihood and Bayesian approaches for fitting demographic models to forest census data sets, demographic models that can then be used to quantitatively assess the role of different competitive coexistence mechanisms.
The current goal of our research is to learn enough about the physiology and ecology of microbes and microbial communities in the gut that we are able to engineer the gut microbiome to improve human health. The first target of our engineering is the production of butyrate – a common fermentation product of some gut microbes that is essential for human health. Butyrate is the preferred energy source for mitochondria in the epithelial cells lining the gut and it also regulates their gene expression.
One of the most effective ways to influence the composition and metabolism of the gut microbiota is through diet. In an interventional study, we have tracked responses in the composition and fermentative metabolism of the gut microtiota in >800 healthy individuals. Emerging patterns suggest several configurations of the microbiome that can result in increased production of butyrate acid. We have isolated the microbes that form an anaerobic food web to convert dietary fiber to butyrate and continue to make discoveries about their physiology and interactions. Based on these results, we have initiated a clinical trial in which we are hoping to prevent the development of Graft versus Host Disease following bone marrow transplants by managing butyrate production by the gut microbiota.
We are also beginning to track hundreds of other metabolites from the gut microbiome that may influence human health. We use metagenomes and metabolomes to identify patterns that link the microbiota with their metabolites and then test those models in human organoids and gnotobiotic mice colonized with synthetic communities of microbes. This blend of wet-lab research in basic microbiology, data science and in ecology is moving us closer to engineering the gut microbiome to improve human health.
Cyber-security is a complex and multi-dimensional research field. My research style comprises an inter-disciplinary (primarily rooted in economics, econometrics, data science (AI/ML/Bayesian and Frequentist Statistics), game theory, and network science) investigation of major socially pressing issues impacting the quality of cyber-risk management in modern networked and distributed engineering systems such as IoT-driven critical infrastructures, cloud-based service networks, and app-based systems (e.g., mobile commerce, smart homes) to name a few. I take delight in proposing data-driven, rigorous, and interdisciplinary solutions to both, existing fundamental challenges that pose a practical bottleneck to (cost) effective cyber-risk management, and futuristic cyber-security and privacy issues that might plague modern (networked) engineering systems. I strongly strive for originality, practical significance, and mathematical rigor in my solutions. One of my primary end goals is to conceptually get arms around complex, multi-dimensional information security and privacy problems in a way that helps, informs, and empowers practitioners and policy makers to take the right steps in making the cyber-space more secure.
The Aguilar group is focused understanding transcriptional and epigenetic mechanisms of skeletal muscle stem cells in diverse contexts such as regeneration after injury and aging. We focus on this area because there are little to no therapies for skeletal muscle after injury or aging. We use various types of in-vivo and in-vitro models in combination with genomic assays and high-throughput sequencing to study these molecular mechanisms.
My methodological research focus on developing statistical methods for routinely collected healthcare databases such as electronic health records (EHR) and claims data. I aim to tackle the unique challenges that arise from the secondary use of real-world data for research purposes. Specifically, I develop novel causal inference methods and semiparametric efficiency theory that harness the full potential of EHR data to address comparative effectiveness and safety questions. I develop scalable and automated pipelines for curation and harmonization of EHR data across healthcare systems and coding systems.