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Ho-Joon Lee

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Dr. Lee’s research in data science concerns biological questions in systems biology and network medicine by developing algorithms and models through a combination of statistical/machine learning, information theory, and network theory applied to multi-dimensional large-scale data. His projects have covered genomics, transcriptomics, proteomics, and metabolomics from yeast to mouse to human for integrative analysis of regulatory networks on multiple molecular levels, which also incorporates large-scale public databases such as GO for functional annotation, PDB for molecular structures, and PubChem and LINCS for drugs or small compounds. He previously carried out proteomics and metabolomics along with a computational derivation of dynamic protein complexes for IL-3 activation and cell cycle in murine pro-B cells (Lee et al., Cell Reports 2017), for which he developed integrative analytical tools using diverse approaches from machine learning and network theory. His ongoing interests in methodology include machine/deep learning and topological Kolmogorov-Sinai entropy-based network theory, which are applied to (1) multi-level dynamic regulatory networks in immune response, cell cycle, and cancer metabolism and (2) mass spectrometry-based omics data analysis.

Figure 1. Proteomics and metabolomics analysis of IL-3 activation and cell cycle (Lee et al., Cell Reports 2017). (A) Multi-omics abundance profiles of proteins, modules/complexes, intracellular metabolites, and extracellular metabolites over one cell cycle (from left to right columns) in response to IL-3 activation. Red for proteins/modules/intracellular metabolites up-regulation or extracellular metabolites release; Green for proteins/modules/intracellular metabolites down-regulation or extracellular metabolites uptake. (B) Functional module network identified from integrative analysis. Red nodes are proteins and white nodes are functional modules. Expression profile plots are shown for literature-validated functional modules. (C) Overall pathway map of IL-3 activation and cell cycle phenotypes. (D) IL-3 activation and cell cycle as a cancer model along with candidate protein and metabolite biomarkers. (E) Protein co-expression scale-free network. (F) Power-low degree distribution of the network E. (G) Protein entropy distribution by topological Kolmogorov-Sinai entropy calculated for the network E.


Mahesh Agarwal

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Mahesh Agarwal is Associate Professor of Mathematics and Statistics at the University of Michigan, Dearborn.

Prof. Agarwal’s is primarily interested in number theory, in particular in p-adic L-functions, Bloch-Kato conjecture and automorphic forms. His secondary research interests are polynomials, geometry and math education, Machine Learning, and healthcare analytics.

Jeffrey C. Lagarias

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Jeffrey C. Lagarias is the Harold Mead Stark Collegiate Professor of Mathematics in the College of Literature, Science, and the Arts at the University of Michigan, Ann Arbor.

Prof. Lagarias’ research interests are diverse. His initial training was in analytic and algebraic number theory. After receiving his PhD in 1974, he worked at Bell Laboratories and AT &T Labs until 2003, on problems in many pure and applied fields. Besides number theory, Prof. Lagarias has made contributions in harmonic analysis (wavelets and fractals), mathematical optimization (interior point methods), discrete geometry (tilings and quasicrystals), ergodic theory, low-dimensional topology (complexity of unknotting), and theoretical computer science.

At Michigan Prof. Lagarias has been active in the number theory group over the last few years, with additional work in other fields. His last 25 postings on the arXiv were in: Number Theory (16), Dynamical Systems (3), Classical Analysis and ODE?s (3), Metric Geometry (1), Optimization and Control (1), Spectral Theory (1). His doctoral students typically work on their own topics. Some have worked in topics in number theory: integer factorial ratios, character sum estimates, Diophantine equations with two separated variables; Others have worked in topics in discrete geometry: packings of regular tetrahedra, rigidity of circle configurations.