My methodological research focus on developing statistical methods for routinely collected healthcare databases such as electronic health records (EHR) and claims data. I aim to tackle the unique challenges that arise from the secondary use of real-world data for research purposes. Specifically, I develop novel causal inference methods and semiparametric efficiency theory that harness the full potential of EHR data to address comparative effectiveness and safety questions. I develop scalable and automated pipelines for curation and harmonization of EHR data across healthcare systems and coding systems.
Our team develops machine learning algorithms for the enhancement of outcomes in cataract surgery, the most commonly performed surgery in the world. Our works focuses on developing models for postoperative refraction after cataract surgery and analysis of surgical quality.
Fred Conrad’s research concerns the development of new methods and data sources for conducting social research. His work is largely focused on survey methodology, but he also explores the use of social media content as a complement to survey data and as a source of large-scale qualitative insights. His focus is on data quality and reducing measurement error. For example, live video interviews promote more thoughtful responses, e.g., less straightlining – the tendency to give the same answer to a battery of survey questions, but they also promote less candor when answering questions on sensitive topics. Measurement error in social media include misclassification in the automated interpretation of content using methods such as sentiment analysis and topic modeling, as well as selective self-presentation (only posting flattering content). Equally challenging is not knowing the extent to which users differ from the population to which one might wish to generalize results.
My research interests are in natural language semantics and psycholinguistics, focusing on verbs. I conduct behavioral psycholinguistic experiments with methodologies such as self-paced reading and maze tasks, as well as surveys of linguistic and semantic judgments. I also study semantic variation using corpora and datasets such as the Twitter Decahose, to better understand how words have developed diverging meanings in different communities, age groups, or regions. I use primarily R and Python to collect, manage, and analyze data. I direct the UM WordLab in the linguistics department, working with students (especially undergraduates) on experimental and computational research focusing on lexical representations.
We are interested in resolving outstanding fundamental scientific problems that impede the computational materials design process. Our group uses high-throughput density functional theory, applied thermodynamics, and materials informatics to deepen our fundamental understanding of synthesis-structure-property relationships, while exploring new chemical spaces for functional technological materials. These research interests are driven by the practical goal of the U.S. Materials Genome Initiative to accelerate materials discovery, but whose resolution requires basic fundamental research in synthesis science, inorganic chemistry, and materials thermodynamics.
As a board-certified ophthalmologist and glaucoma specialist, I have more than 15 years of clinical experience caring for patients with different types and complexities of glaucoma. In addition to my clinical experience, as a health services researcher, I have developed experience and expertise in several disciplines including performing analyses using large health care claims databases to study utilization and outcomes of patients with ocular diseases, racial and other disparities in eye care, associations between systemic conditions or medication use and ocular diseases. I have learned the nuances of various data sources and ways to maximize our use of these data sources to answer important and timely questions. Leveraging my background in HSR with new skills in bioinformatics and precision medicine, over the past 2-3 years I have been developing and growing the Sight Outcomes Research Collaborative (SOURCE) repository, a powerful tool that researchers can tap into to study patients with ocular diseases. My team and I have spent countless hours devising ways of extracting electronic health record data from Clarity, cleaning and de-identifying the data, and making it linkable to ocular diagnostic test data (OCT, HVF, biometry) and non-clinical data. Now that we have successfully developed such a resource here at Kellogg, I am now collaborating with colleagues at > 2 dozen academic ophthalmology departments across the country to assist them with extracting their data in the same format and sending it to Kellogg so that we can pool the data and make it accessible to researchers at all of the participating centers for research and quality improvement studies. I am also actively exploring ways to integrate data from SOURCE into deep learning and artificial intelligence algorithms, making use of SOURCE data for genotype-phenotype association studies and development of polygenic risk scores for common ocular diseases, capturing patient-reported outcome data for the majority of eye care recipients, enhancing visualization of the data on easy-to-access dashboards to aid in quality improvement initiatives, and making use of the data to enhance quality of care, safety, efficiency of care delivery, and to improve clinical operations. .
For human-machine systems, I first collect data from human users, whether it’s an individual, a team, or even a society. Different kinds of methods can be used, including self-report, interview, focus groups, physiological and behavioral data, as well as user-generated data from the Internet.
Based on the data collected, I attempt to understand human contexts, including different aspects of the human users, such as emotion, cognition, needs, preferences, locations and activities. Such understanding can then be applied to different human-machine systems, including healthcare systems, automated driving systems, and product-service systems.
Based on the different design theory and methodology, from the perspective of the machine dimension, I apply knowledge of computing and communication as well as practical and theoretical knowledge of social and behavior to design various systems for human users. From the human dimension, I seek to understand human needs and decision making processes, and then build mathematical models and design tools that facilitate integration of subjective experiences, social contexts, and engineering principles into the design process of human-machine systems.
Dr. Douville is a critical care anesthesiologist with an investigative background in bioinformatics and perioperative outcomes research. He studies techniques for utilizing health care data, including genotype, to deliver personalized medicine in the perioperative period and intensive care unit. His research background has focused on ways technology can assist health care delivery to improve patient outcomes. This began designing microfluidic chips capable of recreating fluid mechanics of atelectatic alveoli and monitoring the resulting barrier breakdown real-time. His interest in bioinformatics was sparked when he observed how methodology designed for tissue engineering could be modified to the nano-scale to enable genomic analysis. Additionally, his engineering training provided the framework to apply data-driven modeling techniques, such as finite element analysis, to complex biological systems.
My research focuses on the causes, dynamics and outcomes of conflict, at the international and local levels. My methodological areas of interest include spatial statistics, mathematical/computational modeling and text analysis.
Map/time-series/network plot, showing the flow of information across battles in World War II. Z axis is time, X and Y axes are longitude and latitude, polygons are locations of battles, red lines are network edges linking battles involving the same combatants. Source: https://doi.org/10.1017/S0020818318000358