His research interest lies in the intersection of signal processing, data science, machine learning, and numerical optimization. He is particularly interested in computational methods for learning low-complexity models from high-dimensional data, leveraging tools from machine learning, numerical optimization, and high dimensional geometry, with applications in imaging sciences, scientific discovery, and healthcare. Recently, he is also interested in understanding deep networks through the lens of low-dimensional modeling.
Our research is focused on Post ICU pain syndromes (PIPS). PIPS exhibit distinct phenotypic presentations and can be predicted by intra-ICU parameters. Our primary goal is to be able to predict post-ICU opioid use based on intra-ICU parameters. We utilize a data-driven characterization of post-ICU pain syndromes will utilize unsupervised clustering algorithms including DBSCAN and spectral clustering. Prediction of post-discharge pain severity, likelihood of specific pain presentations, and post-discharge opioid use will be achieved using logistic LASSO, random forests, and neural networks. Specifically, these tests will utilize available ICU data to predict changes between pre-
and post-ICU pain severity, incidence of specific pain presentations, and incidence of opioid use.
Dr. Hadjiyski research interests include computer-aided diagnosis, artificial intelligence (AI), machine learning, predictive models, image processing and analysis, medical imaging, and control systems. His current research involves design of decision support systems for detection and diagnosis of cancer in different organs and quantitative analysis of integrated multimodality radiomics, histopathology and molecular biomarkers for treatment response monitoring using AI and machine learning techniques. He also studies the effect of the decision support systems on the physicians’ clinical performance.
Multi-center clinical trials increasingly utilize quantitative diffusion imaging (DWI) to aid in patient management and treatment response assessment for translational oncology applications. A major source of systematic bias in diffusion was discovered originating from platform-dependent gradient hardware. Left uncorrected, these biases confound quantitative diffusion metrics used for characterization of tissue pathology and treatment response leading to inconclusive findings, and increasing the requisite subject numbers and trial cost. We have developed technology to mitigate systematic diffusion mapping bias that exists on MRI scanners and are in process of deploying this technology for multi-center clinical trials. Another major source of variance and bottleneck in high-throughput analysis of quantitative diffusion maps is segmentation of tumor/tissue volume of interest (VOI) based on intensities and patterns on multi-contrast MR image datasets, as well as reliable assessment of longitudinal change with disease progression or response to treatment. Our goal is development/trial/application AI algorithms for robust (semi-) automated VOI definition in analysis of multi-dimensional MR datasets for oncology trials.
Dr. Gen Li is an Assistant Professor in the Department of Biostatistics. He is devoted to developing new statistical methods for analyzing complex biomedical data, including multi-way tensor array data, multi-view data, and compositional data. His methodological research interests include dimension reduction, predictive modeling, association analysis, and functional data analysis. He also has research interests in scientific domains including microbiome and genomics.
Uncertainty quantification and decision making are increasingly demanded with the development of future technology in engineering and transportation systems. Among the uncertainty quantification problems, Dr. Wenbo Sun is particularly interested in statistical modelling of engineering system responses with considering the high dimensionality and complicated correlation structure, as well as quantifying the uncertainty from a variety of sources simultaneously, such as the inexactness of large-scale computer experiments, process variations, and measurement noises. He is also interested in data-driven decision making that is robust to the uncertainty. Specifically, he delivers methodologies for anomaly detection and system design optimization, which can be applied to manufacturing process monitoring, distracted driving detection, out-of-distribution object identification, vehicle safety design optimization, etc.
Broadly, I study legal decision making, including decisions related to crime and employment. I typically use large social science data bases, but also collect my own data using technology or surveys.
In this project, we use multi-scale models coupled with machine learning algorithms to study cardiac electromechanic coupling. The approach spans out the molecular, Brownian, and Langevin dynamics of the contractile (sarcomeric proteins) mechanism of cardiac cells and up-to-the finite element analysis of the tissue and organ levels. In this work, a novel surrogate machine learning algorithm for the sarcomere contraction is developed. The model is trained and established using in-silico data-driven dynamic sampling procedures implemented using our previously derived myofilament mathematical models.
Lu’s research is focused on natural language processing, computational social science, and machine learning. More specifically, Lu works on algorithms for text summarization, language generation, argument mining, information extraction, and discourse analysis, as well as novel applications that apply such techniques to understand media bias and polarization and other interdisciplinary subjects.