Relevant Projects:

Discovery and Characterization of Natural Product Systems, Development of natural product inhibitors of Nef for clearance of HIV reservoirs, Discovery and characterization of new toxins in genomes and metagenomes of bloom-forming cyanobacteria, Identify and Characterize Novel Secondary Metabolites produced by Oral Commensals (industry), Interrogation of C-H functionalization technologies in the context of complex pharmaceutically relevant applications

David H. Sherman

Hans W. Vahlteich Professor of Medicinal Chemistry, Research Professor, Life Sciences Institute, Professor of Chemistry, Professor of Microbiology & Immunology

Department of Medicinal Chemistry, College of Pharmacy

Hans W Vahlteich Professor of Medicinal Chemistry, Professor of Medicinal Chemistry, College of Pharmacy, Professor of Microbiology and Immunology, Medical School, Professor of Chemistry, College of Literature, Science, and the Arts and Research Professor, Life Sciences Institute

My group is interested in the discovery and characterization of natural product molecules for pharmaceutical development. Our pipeline relating to data science begins with microbial genome sequencing, mining of natural product biosynthetic gene clusters, integration of LC-MS/MS, and biological activity data. A major challenge in the field of natural product sciences is to 3-dimensional structures of complex metabolites based on genome sequencing data. Advancing this challenge will provide access to millions of new chemical structures with potential important disease fighting activities derived from cheap, rapid, next-gen sequencing technologies. Moreover, accurate prediction of complex natural product structures from genome sequencing data would then allow virtual screening of compounds against important disease targets (e.g. ribosomes, kinases, receptors) to begin the drug discovery process. It would also enable virtual medicinal chemistry to optimize molecules for disease target binding and optimal bioavailability and pharmacokinetic properties.


Research Highlights