The overarching theme of Carl’s research for the past two decades is interoperability in information systems, spanning the full spectrum of the technical and human components that are critical to create networked information systems that really work. Although the results of this research apply across a variety of information contexts, the primary thread of my research explores information systems to support scholarship and knowledge production. The principal question he asks is: how do we build and sustain cyberinfrastructure that supports the full cycle scholarship and that respects the cultural, methodological, and social variance among fields of scholarship? Some relevant sub questions of this primary issue are: what are the methodological approaches and theoretical foundations relevant to understanding the nuanced variations and scholars’ attitudes towards technical cyberinfrastructure? And: how do we design technical cyberinfrastructure that simultaneously supports large-scale interoperability it respects the diversity scholarship? Finally: How do we accommodate multiple levels of expertise (e.g., citizen scientists) while maintaining quality and integrity? These are essential questions to him “At a time of significant investment in cyberinfrastructure by governments and funders and the emergence of critical scientific questions such as climate change and global pandemics, the investigation of which requires cross-disciplinary collaborations and cyberinfrastructure support.”