My group investigates hypertension using a principally patient-oriented approach, with key aspects of our work being collaborative with data scientists. For example, I collaborated with Casey Greene, PhD, computational biologist, on a project using generative adversarial neural networks to create a privacy-preserving dataset derivative of the SPRINT hypertension clinical trial. The work incorporated concepts from the differential privacy field, and the intent is to make clinical trial data sharing more feasible.
My research interests include health effects of air pollution, temperature extremes and climate change (mortality, asthma, hospital admissions, birth outcomes and cardiovascular endpoints); environmental exposure assessment; and socio-economic influences on health.
Data science tools and methodologies include geographic information systems and spatio-temporal analysis, epidemiologic study design and data management.
As an environmental epidemiologist and in collaboration with government and community partners, I study how social, economic, health, and built environment characteristics and/or air quality affect vulnerability to extreme heat and extreme precipitation. This research will help cities understand how to adapt to heat, heat waves, higher pollen levels, and heavy rainfall in a changing climate.
My primary research interests are understanding the causes and consequences of biased selection and attention to persuasive information, particularly in the context of health promotion. Simply stated, I am interested in what we pay attention to and why, and how this attention (or inattention) influences attitudinal and behavioral outcomes, such as persuasion and healthy behavior. In particular, my work has addressed disparities in attention to information about HIV prevention for African-Americans compared to European-Americans as a predictor of disparities in health outcomes. I am also exploring barriers to attention to health information by African-Americans, including the roles of stigma, shame, fear, and perceptions of irrelevance. At a more basic attitudes and persuasion level, I am currently pursuing work relevant to how we select information for liked versus disliked others, and how the role of choice influences how we process information we agree versus disagree with.
Kevin’s research is focused on to identifying and interpreting the mechanisms responsible for the complex dynamics we observe in ecological and epidemiological systems using data science and modeling approaches. He is primarily interested in emerging and endemic pathogens, such as SARS-CoV-2, influenza, vampire bat rabies, and a host of childhood infectious diseases such as chickenpox. He uses statistical and mechanistic models to fit, forecast, and occasionally back-cast expected disease dynamics under a host of conditions, such as vaccination or other control mechanisms.
Dr. Fernandez is a clinical psychologist with extensive training in both addiction and behavioral medicine. She is the Clinical Program Director at the University of Michigan Addiction Treatment Service. Her research focuses on the intersection of addiction and health across two main themes: 1) Expanding access to substance use disorder treatment and prevention services particularly in healthcare settings and; 2) applying precision health approaches to addiction-related healthcare questions. Her current grant-funded research includes an NIH-funded randomized controlled pilot trial of a preoperative alcohol intervention, an NIH-funded precision health study to leverage electronic health records to identify high-risk alcohol use at the time of surgery using natural language processing and other machine-learning based approaches, a University of Michigan funded precision health award to understand and prevent new persistent opioid use after surgery using prediction modeling, and a federally-funded evaluation of the state of Michigan’s substance use disorder treatment expansion.
My research focuses on the development and evaluation of novel interventions that leverage emerging technologies to train members of the healthcare workforce around adhering to guidelines. I study how to scale custom designed teaching and learning platforms and evaluate their use to motivate effective communication and dissemination of evidence based practice. Other emphases of my work include health policy literacy, translation and communication of health services research, and improving health system literacy in urban communities. I have developed and evaluated numerous web based educational interventions that employ the “flipped classroom” design with an emphasis on understanding the data and analytics that guide successful implementation and promote high fidelity for members of the healthcare workforce. As an implementation scientist, I rely on the integration of data and analytics to understand what motivates successful program implementation.
In addition to the development of these platforms, I have extensive experience developing and evaluating online, hybrid residential, residential courses, and MOOCs related to healthcare management, non-profit management, healthcare finance, and health economics that employ engaging lessons and modules, interactive graphics, and a blended learning format to aid health professions students, and both undergraduate and graduate public health students in understanding the healthcare system. My MOOC entitled “Understanding and Improving the U.S. Health Care System” has been taken by over 5,000 learners and is characterized by the use of “big data” to understand how future healthcare providers learn health policy.
Rahul Ladhania is an Assistant Professor of Health Informatics in the Department of Health Management & Policy at the University of Michigan School of Public Health. He also has a secondary (courtesy) appointment with the Department of Biostatistics at SPH. Rahul’s research is in the area of causal inference and machine learning in public and behavioral health. A large body of his work focuses on estimating personalized treatment rules and heterogeneous effects of policy, digital and behavioral interventions on human behavior and health outcomes in complex experimental and observational settings using statistical machine learning methods.
Rahul co-leads the Machine Learning team at the Behavior Change For Good Initiative (Penn), where he is working on two `mega-studies’ (very large multi-arm randomized trials): one in partnership with a national fitness chain, to estimate the effects of behavioral interventions on promoting gym visit habit formation; and the other in partnership with two large Mid-Atlantic health systems and a national pharmacy chain, to estimate the effects of text-based interventions on increasing flu shot vaccination rates. His other projects involve partnerships with step-counting apps and mobile-based games to learn user behavior patterns, and design and evaluate interventions and their heterogeneous effects on user behavior.
My research interest lies in applying data science for actionable transformation of human health from the bench to bedside. Current research focus areas include cutting edge single-cell sequencing informatics and genomics; precision medicine through integration of multi-omics data types; novel modeling and computational methods for biomarker research; public health genomics. I apply my biomedical informatics and analytical expertise to study diseases such as cancers, as well the impact of pregnancy/early life complications on later life diseases.
My methodological research focus on developing statistical methods for routinely collected healthcare databases such as electronic health records (EHR) and claims data. I aim to tackle the unique challenges that arise from the secondary use of real-world data for research purposes. Specifically, I develop novel causal inference methods and semiparametric efficiency theory that harness the full potential of EHR data to address comparative effectiveness and safety questions. I develop scalable and automated pipelines for curation and harmonization of EHR data across healthcare systems and coding systems.