The Ahmed lab studies behavioral neural circuits and attempts to repair them when they go awry in neurological disorders. Working with patients and with transgenic rodent models, we focus on how space, time and speed are encoded by the spatial navigation and memory circuits of the brain. We also focus on how these same circuits go wrong in Alzheimer’s disease, Parkinson’s disease and epilepsy. Our research involves the collection of massive volumes of neural data. Within these terabytes of data, we work to identify and understand irregular activity patterns at the sub-millisecond level. This requires us to leverage high performance computing environments, and to design custom algorithmic and analytical signal processing solutions. As part of our research, we also discover new ways for the brain to encode information (how neurons encode sequences of space and time, for example) – and the algorithms utilized by these natural neural networks can have important implications for the design of more effective artificial neural networks.
My methodological research focus on developing statistical methods for routinely collected healthcare databases such as electronic health records (EHR) and claims data. I aim to tackle the unique challenges that arise from the secondary use of real-world data for research purposes. Specifically, I develop novel causal inference methods and semiparametric efficiency theory that harness the full potential of EHR data to address comparative effectiveness and safety questions. I develop scalable and automated pipelines for curation and harmonization of EHR data across healthcare systems and coding systems.
Dr. Likosky is a Professor, Head of the Section of Health Services Research and Quality in the Department of Cardiac Surgery at Michigan Medicine and faculty member at the Center for Healthcare Outcomes and Policy. Dr. Likosky’s work currently focuses on leveraging: (i) mobile health technology to identify objective and scalable measures for mitigating post-surgical morbidities, and (ii) computer vision to identify objective and scalable measures of important intraoperative technical skills and non-technical practices.
Professor Kowalski’s recent research analyzes experiments and clinical trials with the goal of designing policies to target insurance expansions and medical treatments to individuals who stand to benefit from them the most. Her research has also explored the impact of previous Medicaid expansions, the Affordable Care Act, the Massachusetts health reform of 2006, and employer-sponsored health insurance plans. She has also used cutting-edge techniques to estimate the value of medical spending on at-risk newborns.
My research is at the intersection of neuroscience and artificial intelligence. My group uses neuroscience or brain-inspired principles to design models and algorithms for computer vision and language processing. In turn, we uses neural network models to test hypotheses in neuroscience and explain or predict human perception and behaviors. My group also develops and uses machine learning algorithms to improve the acquisition and analysis of medical images, including functional magnetic resonance imaging of the brain and magnetic resonance imaging of the gut.
We use brain-inspired neural networks models to predict and decode brain activity in humans processing information from naturalistic audiovisual stimuli.
My research focuses on methods, applications, and ethics of Computational Modeling in Human-Computer Interaction (HCI). Understanding and modeling human behavior supports innovative information technology that will change how we study and design interactive user experiences. I envision modeling the human accurately across domains as a theoretical foundation for work in HCI in which computational models provide a foundation to study, describe, and understand complex human behaviors and support optimization and evaluation of user interfaces. I create technology that automatically reasons about and acts in response to people’s behavior to help them be productive, healthy, and safe.
We have developed and tested machine learning approaches to integrate quantitative markers for diagnosis and assessment of progression of TMJ OA, as well as extended the capabilities of 3D Slicer4 into web-based tools and disseminated open source image analysis tools. Our aims use data processing and in-depth analytics combined with learning using privileged information, integrated feature selection, and testing the performance of longitudinal risk predictors. Our long term goals are to improve diagnosis and risk prediction of TemporoMandibular Osteoarthritis in future multicenter studies.
The Spectrum of Data Science for Diagnosis of Osteoarthritis of the Temporomandibular Joint
Dr. Douville is a critical care anesthesiologist with an investigative background in bioinformatics and perioperative outcomes research. He studies techniques for utilizing health care data, including genotype, to deliver personalized medicine in the perioperative period and intensive care unit. His research background has focused on ways technology can assist health care delivery to improve patient outcomes. This began designing microfluidic chips capable of recreating fluid mechanics of atelectatic alveoli and monitoring the resulting barrier breakdown real-time. His interest in bioinformatics was sparked when he observed how methodology designed for tissue engineering could be modified to the nano-scale to enable genomic analysis. Additionally, his engineering training provided the framework to apply data-driven modeling techniques, such as finite element analysis, to complex biological systems.
I use machine-learning techniques to implement decision support systems and tools that facilitate more personalized care for disease management and healthcare utilization to ultimately deliver efficient, effective, and equitable therapy for chronic diseases. To test and advance these general principles, I have built operational programs that are guiding—and improving—patient care in costly in low resource settings, including emerging countries.