Alexander Rodríguez

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Alex’s research interests include machine learning, time series, multi-agent systems, uncertainty quantification, and scientific modeling. His recent focus is on developing trustworthy AI systems that can offer insightful guidance for critical decisions, especially in applications involving complex spatiotemporal dynamics. His work is primarily motivated by real-world problems in public health, environmental health and community resilience.

Irina Gaynanova

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Dr. Gaynanova’s research focuses on the development of statistical methods for analysis of modern high-dimensional biomedical data. Her methodological interests are in data integration, machine learning and high-dimensional statistics, motivated by challenges arising in analyses of multi-omics data (e.g., RNASeq, metabolomics, micribiome) and data from wearable devices (continuous glucose monitors, ambulatory blood pressure monitors, activity trackers).Dr. Gaynanova’s research has been funded by the National Science Foundation, and recognized with a David P. Byar Young Investigator Award and an NSF CAREER Award. She currently serves as an Associate Editor for Journal of the American Statistical Association, Biometrika and Data Science in Science.

Tian An Wong

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Analysis of policing technology and police data, including impact assessment of surveillance technology, media sentiment analysis, and fatal police violence. Methods include topological data analysis, natural language processing, multivariate time series analysis, difference-in-differences, and complex networks.

 


Research Highlights

Cristian Minoccheri

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Dr. Minoccheri’s research interests focus on using mathematical tools to enhance existing machine learning methods and develop novel ones. A central topic is the use of tensor methods, multilinear algebra, and invariant theory to leverage higher order structural properties in data mining, classification, and deep learning. Other research interests include interpretable machine learning and transparent models. The main applications are in the computational medicine domain, such as phenotyping, medical image segmentation, drug design, patients’ prognosis.

Mark Draelos

Mark Draelos

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My work focuses on image-guided medical robots with an emphasis on clinical translation. My interests include medical robotics, biomedical imaging, data visualization, medical device development, and real-time algorithms.

A major ongoing project is the development of robotic system for automated eye examination. This system relies on machine learning models for tracking and eventually for interpretation of collected data. Other projects concern the live creation of virtual reality scenes from volumetric imaging modalities like optical coherence tomography and efficient acquisition strategies for such purposes.

John Prensner

John Prensner

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My research group uses molecular techniques and computational methods to dissect the biology of pediatric cancers. We are invested in fundamental genomic discovery of non-canonical open reading frames that are dysregulated in cancer. We use functional genomics techniques to facilitate biological analysis. We employ data science methodologies to model and predict the molecular biology of cancers. Our particular focus is on RNA translation and its regulation. We also focus on therapeutic interventions that may represent novel treatment strategies for cancer.

What are some of your most interesting projects?

I am fascinated by the ways in which cancer cells pattern RNA translation. We are currently performing large-scale -omic analyses to identify patterns in RNA translational control across pediatric brain cancers.

How did you end up where you are today?

I came to science late in life. I studied English Literature as an undergraduate at Tufts University before deciding to study biochemistry as a senior in college. This led me to join a cancer biology lab after college, which motivated me to go to medical school. I enrolled in the University of Michigan Medical School in 2006 but quickly became interested in the biology of cancer. I then joined the Medical Scientist Training Program and graduated with an MD/PhD dual degree in 2014. I pursued Pediatrics clinical training at Boston Children’s Hospital and pediatric hematology/oncology at Dana-Farber Cancer Institute. I then completed post-doctoral research at the Broad Institute of MIT and Harvard prior to joining the faculty of the University of Michigan.

What is the most significant scientific contribution you would like to make?

My goal is to cure childhood brain cancers. That is what motivates me every day!

Chuan Zhou

Chuan Zhou

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With a passion for developing decision support systems that integrate cutting edge techniques from artificial intelligence, quantitative image analysis, computer vision, and multimodal biomedical data fusion. Research interests have been focusing on characterizing diseases abnormalities and predicting their likelihood of being significant, with the goal to enable early diagnosis and risk stratification, as well as aiding treatment decision making and monitoring.

Liyue Shen

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My research interest is in Biomedical AI, which lies in the interdisciplinary areas of machine learning, computer vision, signal and image processing, medical image analysis, biomedical imaging, and data science. I am particularly interested in developing efficient and reliable AI/ML-driven computational methods for biomedical imaging and informatics to tackle real-world biomedicine and healthcare problems, including but not limited to, personalized cancer treatment, and precision medicine.

In the field of AI/ML, we focus on developing reliable, generalizable, data-efficient machine learning and deep learning algorithms by exploiting prior knowledge from the physical world, such as: Prior-integrated learning for data-efficient ML Uncertainty awareness for trustworthy ML. In the field of Biomedicine, we focus on developing efficient computational methods for biomedical imaging and biomedical data analysis to advance precision medicine and personalized treatment, such as: Multi-modal data analysis for decision making Clinical trial translation for real-world deployment.

In the field of AI/ML, we focus on developing reliable, generalizable, data-efficient machine learning and deep learning algorithms by exploiting prior knowledge from the physical world, such as: Prior-integrated learning for data-efficient ML Uncertainty awareness for trustworthy ML. In the field of Biomedicine, we focus on developing efficient computational methods for biomedical imaging and biomedical data analysis to advance precision medicine and personalized treatment, such as: Multi-modal data analysis for decision making Clinical trial translation for real-world deployment.

What are some of your most interesting projects?

Our goal is to develop efficient and reliable AI/ML-driven computational methods for biomedical imaging and informatics to tackle real-world biomedicine and healthcare problems. We hope the technology advancement in AI and ML can help us to better understand human health in different levels. Specifically, we develop Biomedical AI in different parts, including:
– AI in Biomedical Imaging: develop novel machine learning algorithms to advance biomedical imaging techniques for obtaining computational images with improved quality. Specifically, relevant topics include but not limited to: Implicit neural representation learning; Diffusion model / Score-based generative model; Physics-aware / Geometry-informed deep learning.
– AI in Biomedical Image Processing and Bioinformatics: develop robust and efficient machine learning algorithms to extract useful information from multimodal biomedical data for assisting decision making and precision medicine. Specifically, relevant topics include but not limited to: Multimodal representation learning; Robust learning with missing data / noisy labeling; Data-efficient learning such as self- / un- / semi-supervised learning with limited data / labels.

How did you end up where you are today?

I am an assistant professor in the ECE Division of the Electrical Engineering and Computer Science department of the College of Engineering, University of Michigan – Ann Arbor. Before this, I received my Ph.D. degree from the Department of Electrical Engineering, Stanford University. I obtained her Bachelor’s degree in Electronic Engineering from Tsinghua University in 2016. I is the recipient of Stanford Bio-X Bowes Graduate Student Fellowship (2019-2022), and was selected as the Rising Star in EECS by MIT and the Rising Star in Data Science by The University of Chicago in 2021.


Accomplishments and Awards

David Williams

David Williams

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I have several areas of study that touch on the fields of Data Science.

First I am the UM PI of PCORnet a national network of over 80 institutions that support clinical research. PCORnet possesses a common data model allowing for the harmonization of the electronic health record across the network. The common data model is helpful in cohort discovery, development of computable phenotypes, the study of rare diseases, and applications of machine learning for identifying patterns in disease and health care services that can help to form better models of precision care.

My second area of interest is in the use of big data to support behavioral change. PainGuide is a digital pain self-management program developed at UM that offers a variety of evidence-based methods for improving and managing pain. User data can inform AI algorithms to refine content and recommendations for the participants so as to personalize care and improve outcomes.