I am Research Faculty with the Michigan Center for Integrative Research in Critical Care (MCIRCC). Our team builds predictive algorithms, analyzes signals, and implements statistical models to advance Critical Care Medicine. We use electronic healthcare record data to build predictive algorithms. One example of this is Predicting Intensive Care Transfers and other Unforeseen Events (PICTURE), which uses commonly collected vital signs and labs to predict patient deterioration on the general hospital floor. Additionally, our team collects waveforms from the University Hospital, and we store this data utilizing Amazon Web Services. We use these signals to build predictive algorithms to advance precision medicine. Our flagship algorithm called Analytic for Hemodynamic Instability (AHI), predicts patient deterioration using a single-lead electrocardiogram signal. We use Bayesian methods to analyze metabolomic biomarker data from blood and exhaled breath to understand Sepsis and Acute Respiratory Distress Syndrome. I also have an interest in statistical genetics.
Hyun Min Kang is an Associate Professor in the Department of Biostatistics. He received his Ph.D. in Computer Science from University of California, San Diego in 2009 and joined the University of Michigan faculty in the same year. Prior to his doctoral studies, he worked as a research fellow at the Genome Research Center for Diabetes and Endocrine Disease in the Seoul National University Hospital for a year and a half, after completing his Bachelors and Masters degree in Electrical Engineering at Seoul National University. His research interest lies in big data genome science. Methodologically, his primary focus is on developing statistical methods and computational tools for large-scale genetic studies. Scientifically, his research aims to understand the etiology of complex disease traits, including type 2 diabetes, bipolar disorder, cardiovascular diseases, and glomerular diseases.
Dr. Veera Baladandayuthapani is currently a Professor in the Department of Biostatistics at University of Michigan (UM), where he is also the Associate Director of the Center for Cancer Biostatistics. He joined UM in Fall 2018 after spending 13 years in the Department of Biostatistics at University of Texas MD Anderson Cancer Center, Houston, Texas, where was a Professor and Institute Faculty Scholar and held adjunct appointments at Rice University, Texas A&M University and UT School of Public Health. His research interests are mainly in high-dimensional data modeling and Bayesian inference. This includes functional data analyses, Bayesian graphical models, Bayesian semi-/non-parametric models and Bayesian machine learning. These methods are motivated by large and complex datasets (a.k.a. Big Data) such as high-throughput genomics, epigenomics, transcriptomics and proteomics as well as high-resolution neuro- and cancer- imaging. His work has been published in top statistical/biostatistical/bioinformatics and biomedical/oncology journals. He has also co-authored a book on Bayesian analysis of gene expression data. He currently holds multiple PI-level grants from NIH and NSF to develop innovative and advanced biostatistical and bioinformatics methods for big datasets in oncology. He has also served as the Director of the Biostatistics and Bioinformatics Cores for the Specialized Programs of Research Excellence (SPOREs) in Multiple Myeloma and Lung Cancer and Biostatistics&Bioinformatics platform leader for the Myeloma and Melanoma Moonshot Programs at MD Anderson. He is a fellow of the American Statistical Association and an elected member of the International Statistical Institute. He currently serves as an Associate Editor for Journal of American Statistical Association, Biometrics and Sankhya.
I study how law shapes innovation in the life sciences, with a substantial focus on big data and artificial intelligence in medicine. I write about the intellectual property incentives and protections for data and AI algorithms, the privacy issues with wide-scale health- and health-related data collection, the medical malpractice implications of AI in medicine, and how FDA should regulate the use of medical AI.
My research is focused on developing efficient and effective statistical and computational methods for genetic and genomic studies. These studies often involve large-scale and high-dimensional data; examples include genome-wide association studies, epigenome-wide association studies, and various functional genomic sequencing studies such as bulk and single cell RNAseq, bisulfite sequencing, ChIPseq, ATACseq etc. Our method development is often application oriented and specifically targeted for practical applications of these large-scale genetic and genomic studies, thus is not restricted in a particular methodology area. Our previous and current methods include, but are not limited to, Bayesian methods, mixed effects models, factor analysis models, sparse regression models, deep learning algorithms, clustering algorithms, integrative methods, spatial statistics, and efficient computational algorithms. By developing novel analytic methods, I seek to extract important information from these data and to advance our understanding of the genetic basis of phenotypic variation for various human diseases and disease related quantitative traits.
Samuel K Handelman, Ph.D., is Research Assistant Professor in the department of Internal Medicine, Gastroenterology, of Michigan Medicine at the University of Michigan, Ann Arbor. Prof. Handelman is focused on multi-omics approaches to drive precision/personalized-therapy and to predict population-level differences in the effectiveness of interventions. He tends to favor regression-style and hierarchical-clustering approaches, partially because he has a background in both statistics and in cladistics. His scientific monomania is for compensatory mechanisms and trade-offs in evolution, but he has a principled reason to focus on translational medicine: real understanding of these mechanisms goes all the way into the clinic. Anything less that clinical translation indicates that we don’t understand what drove the genetics of human populations.
Srijan Sen, MD, PhD, is the Frances and Kenneth Eisenberg Professor of Depression and Neurosciences. Dr. Sen’s research focuses on the interactions between genes and the environment and their effect on stress, anxiety, and depression. He also has a particular interest in medical education, and leads a large multi-institution study that uses medical internship as a model of stress.
Jun Li, PhD, is Professor and Chair for Research in the department of Computational Medicine and Bioinformatics and Professor of Human Genetics in the Medical School at the University of Michigan, Ann Arbor.
Bhramar Mukherjee is a Professor in the Department of Biostatistics, joining the department in Fall, 2006. Bhramar is also a Professor in the Department of Epidemiology. Bhramar completed her Ph.D. in 2001 from Purdue University. Bhramar’s principal research interests lie in Bayesian methods in epidemiology and studies of gene-environment interaction. She is also interested in modeling missingness in exposure, categorical data models, Bayesian nonparametrics, and the general area of statistical inference under outcome/exposure dependent sampling schemes. Bhramar’s methodological research is funded by NSF and NIH. Bhramar is involved as a co-investigator in several R01s led by faculty in Internal Medicine, Epidemiology and Environment Health sciences at UM. Her collaborative interests focus on genetic and environmental epidemiology, ranging from investigating the genetic architecture of colorectal cancer in relation to environmental exposures to studies of air pollution on pediatric Asthma events in Detroit. She is actively engaged in Global Health Research.
Sebastian Zöllner is a Professor of Biostatistics. He also holds an appointment in the Department of Psychiatry. Dr. Zöllner joined the University of Michigan after a postdoctoral fellowship in the Department of Human Genetics at the University of Chicago. His research effort is divided between generating new methods in statistical genetics and analyzing data. The general thrust of his work is problems from human genetics, evolutionary biology and statistical population biology.