Lana Garmire

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My research interest lies in applying data science for actionable transformation of human health from the bench to bedside. Current research focus areas include cutting edge single-cell sequencing informatics and genomics; precision medicine through integration of multi-omics data types; novel modeling and computational methods for biomarker research; public health genomics. I apply my biomedical informatics and analytical expertise to study diseases such as cancers, as well the impact of pregnancy/early life complications on later life diseases.

Stephan F. Taylor

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STEPHAN F. TAYLOR is a professor of psychiatry and Associate Chair for Research and Research Regulatory Affairs in the Department of Psychiatry; and an adjunct professor of psychology.

His work uses brain mapping and brain stimulation to study and treat serious mental disorders such as psychosis, refractory depression and obsessive-compulsive disorder. Data science techniques area applied in the analysis of high dimensional functional magnetic resonance imaging datasets and meso-scale brain networks, using supervised and unsupervised techniques to interrogate brain-behavior correlations relevant for psychopathological conditions. Clinical-translation work with brain stimulation, primarily with transcranial magnetic stimulation, is informed by mapping meso-scale networks to guide treatment of conditions such as depression. Future work seeks to use machine learning to identify treatment predictors and match individual patients to specific treatments.

Xu Shi

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My methodological research focus on developing statistical methods for routinely collected healthcare databases such as electronic health records (EHR) and claims data. I aim to tackle the unique challenges that arise from the secondary use of real-world data for research purposes. Specifically, I develop novel causal inference methods and semiparametric efficiency theory that harness the full potential of EHR data to address comparative effectiveness and safety questions. I develop scalable and automated pipelines for curation and harmonization of EHR data across healthcare systems and coding systems.

Evan Keller

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Our laboratory focuses on (1) the biology of cancer metastasis, especially bone metastasis, including the role of the host microenvironment; and (2) mechanisms of chemoresistance. We explore for genes that regulate metastasis and the interaction between the host microenvironment and cancer cells. We are performing single cell multiomics and spatial analysis to enable us to identify rare cell populations and promote precision medicine. Our research methodology uses a combination of molecular, cellular, and animal studies. The majority of our work is highly translational to provide clinical relevance to our work. In terms of data science, we collaborate on applications of both established and novel methodologies to analyze high dimensional; deconvolution of high dimensional data into a cellular and tissue context; spatial mapping of multiomic data; and heterogenous data integration.

Joshua Stein

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As a board-certified ophthalmologist and glaucoma specialist, I have more than 15 years of clinical experience caring for patients with different types and complexities of glaucoma. In addition to my clinical experience, as a health services researcher, I have developed experience and expertise in several disciplines including performing analyses using large health care claims databases to study utilization and outcomes of patients with ocular diseases, racial and other disparities in eye care, associations between systemic conditions or medication use and ocular diseases. I have learned the nuances of various data sources and ways to maximize our use of these data sources to answer important and timely questions. Leveraging my background in HSR with new skills in bioinformatics and precision medicine, over the past 2-3 years I have been developing and growing the Sight Outcomes Research Collaborative (SOURCE) repository, a powerful tool that researchers can tap into to study patients with ocular diseases. My team and I have spent countless hours devising ways of extracting electronic health record data from Clarity, cleaning and de-identifying the data, and making it linkable to ocular diagnostic test data (OCT, HVF, biometry) and non-clinical data. Now that we have successfully developed such a resource here at Kellogg, I am now collaborating with colleagues at > 2 dozen academic ophthalmology departments across the country to assist them with extracting their data in the same format and sending it to Kellogg so that we can pool the data and make it accessible to researchers at all of the participating centers for research and quality improvement studies. I am also actively exploring ways to integrate data from SOURCE into deep learning and artificial intelligence algorithms, making use of SOURCE data for genotype-phenotype association studies and development of polygenic risk scores for common ocular diseases, capturing patient-reported outcome data for the majority of eye care recipients, enhancing visualization of the data on easy-to-access dashboards to aid in quality improvement initiatives, and making use of the data to enhance quality of care, safety, efficiency of care delivery, and to improve clinical operations. .

Akbar Waljee

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I use machine-learning techniques to implement decision support systems and tools that facilitate more personalized care for disease management and healthcare utilization to ultimately deliver efficient, effective, and equitable therapy for chronic diseases. To test and advance these general principles, I have built operational programs that are guiding—and improving—patient care in costly in low resource settings, including emerging countries.

Robert Ploutz-Snyder

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My work falls into three general application areas. I am an applied (accredited) biostatistician with a strong team science motivation and I collaborate with scientists in primarily the biomedical sciences, contributing expertise in experimental design, statistical analysis/modeling, and data visualization. I have held faculty appointments in Schools of Medicine and Nursing, and also worked as a senior scientist in the Human Research Program at the NASA Johnson Space Center. I currently direct an Applied Biostatistics Laboratory and Data Management Core within the UM School of Nursing, and maintain several collaborative research programs within the School, at NASA, and with collaborators elsewhere.

Keith Aaronson, MD

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Dr. Aaronson is actively engaged in clinical practice and clinical research in the areas of heart failure, heart transplantation and mechanical circulatory support. His research has focused on improving health, quality of life and economic outcomes in these populations, utilizing methodologies ranging from small to large scale observational analyses, Markov modeling, meta-analyses, and both industry-sponsored and investigator-initiated randomized clinical trials of standard pharmaceutical interventions, alternative medicines, patient education and mechanical circulatory support. Dr. Aaronson has had a particular interest in modeling outcomes in advanced heart failure, heart transplantation and mechanical circulatory support to inform appropriate utilization of health resources.

Vitaliy Popov

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My research focuses on understanding, designing, and evaluating learning technologies and environments that foster collaborative problem solving, spatial reasoning, engineering design thinking and agency. I am particularly interested in applying multimodal learning analytics in the context of co-located and/or virtually distributed teams in clinical simulations. I strive to utilize evidence in education science, simulation-based training and learning analytics to understand how people become expert health professionals, how they can better work in teams and how we can support these processes to foster health care delivery and health outcomes.

Nicole Seiberlich

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My research involves developing novel data collection strategies and image reconstruction techniques for Magnetic Resonance Imaging. In order to accelerate data collection, we take advantage of features of MRI data, including sparsity, spatiotemporal correlations, and adherence to underlying physics; each of these properties can be leveraged to reduce the amount of data required to generate an image and thus speed up imaging time. We also seek to understand what image information is essential for radiologists in order to optimize MRI data collection and personalize the imaging protocol for each patient. We deploy machine learning algorithms and optimization techniques in each of these projects. In some of our work, we can generate the data that we need to train and test our algorithms using numerical simulations. In other portions, we seek to utilize clinical images, prospectively collected MRI data, or MRI protocol information in order to refine our techniques.

We seek to develop technologies like cardiac Magnetic Resonance Fingerprinting (cMRF), which can be used to efficiently collect multiple forms of information to distinguish healthy and diseased tissue using MRI. By using rapid methods like cMRF, quantitative data describing disease processes can be gathered quickly, enabling more and sicker patients can be assessed via MRI. These data, collected from many patients over time, can also be used to further refine MRI technologies for the assessment of specific diseases in a tailored, patient-specific manner.