Samuel K Handelman, Ph.D., is Research Assistant Professor in the department of Internal Medicine, Gastroenterology, of Michigan Medicine at the University of Michigan, Ann Arbor. Prof. Handelman is focused on multi-omics approaches to drive precision/personalized-therapy and to predict population-level differences in the effectiveness of interventions. He tends to favor regression-style and hierarchical-clustering approaches, partially because he has a background in both statistics and in cladistics. His scientific monomania is for compensatory mechanisms and trade-offs in evolution, but he has a principled reason to focus on translational medicine: real understanding of these mechanisms goes all the way into the clinic. Anything less that clinical translation indicates that we don’t understand what drove the genetics of human populations.
Zhenke Wu is an Assistant Professor of Biostatistics, and Research Assistant Professor in Michigan Institute of Data Science (MIDAS). He received his Ph.D. in Biostatistics from the Johns Hopkins University in 2014 and then stayed at Hopkins for his postdoctoral training before joining the University of Michigan. Dr. Wu’s research focuses on the design and application of statistical methods that inform health decisions made by individuals, or precision medicine. The original methods and software developed by Dr. Wu are now used by investigators from research institutes such as CDC and Johns Hopkins, as well as site investigators from developing countries, e.g., Kenya, South Africa, Gambia, Mali, Zambia, Thailand and Bangladesh.
Brenda Gillespie, PhD, is Associate Director in Consulting for Statistics, Computing and Analytics Research (CSCAR) with a secondary appointment as Associate Research Professor in the department of Biostatistics in the School of Public Health at the University of Michigan, Ann Arbor. She provides statistical collaboration and support for numerous research projects at the University of Michigan. She teaches Biostatistics courses as well as CSCAR short courses in survival analysis, regression analysis, sample size calculation, generalized linear models, meta-analysis, and statistical ethics. Her major areas of expertise are clinical trials and survival analysis.
Prof. Gillespie’s research interests are in the area of censored data and clinical trials. One research interest concerns the application of categorical regression models to the case of censored survival data. This technique is useful in modeling the hazard function (instead of treating it as a nuisance parameter, as in Cox proportional hazards regression), or in the situation where time-related interactions (i.e., non-proportional hazards) are present. An investigation comparing various categorical modeling strategies is currently in progress.
Another area of interest is the analysis of cross-over trials with censored data. Brenda has developed (with M. Feingold) a set of nonparametric methods for testing and estimation in this setting. Our methods out-perform previous methods in most cases.
The goal of my research is to leverage network analysis techniques to uncover how the brain mediates sex hormone influences on gendered behavior across the lifespan. Specifically, my data science research concerns the creation and application of person-specific connectivity analyses, such as unified structural equation models, to time series data; these are intensive longitudinal data, including functional neuroimages, daily diaries, and observations. I then use these data science methods to investigate the links between androgens (e.g., testosterone) and estradiol at key developmental periods, such as puberty, and behaviors that typically show sex differences, including aspects of cognition and psychopathology.
Kai S. Cortina, PhD, is Professor of Psychology in the College of Literature, Science, and the Arts at the University of Michigan, Ann Arbor.
Prof. Cortina’s major research revolves around the understanding of children’s and adolescents’ pathways into adulthood and the role of the educational system in this process. The academic and psycho-social development is analyzed from a life-span perspective exclusively analyzing longitudinal data over longer periods of time (e.g., from middle school to young adulthood). The hierarchical structure of the school system (student/classroom/school/district/state/nations) requires the use of statistical tools that can handle these kind of nested data.
Matthew Kay, PhD, is Assistant Professor of Information, School of Information and Assistant Professor of Electrical Engineering and Computer Science, College of Engineering, at the University of Michigan, Ann Arbor.
Prof. Kay’s research includes work on communicating uncertainty, usable statistics, and personal informatics. People are increasingly exposed to sensing and prediction in their daily lives (“how many steps did I take today?”, “how long until my bus shows up?”, “how much do I weigh?”). Uncertainty is both inherent to these systems and usually poorly communicated. To build understandable data presentations, we must study how people interpret their data and what goals they have for it, which informs the way that we should communicate results from our models, which in turn determines what models we must use in the first place. Prof. Kay tackles these problems using a multi-faceted approach, including qualitative and quantitative analysis of behavior, building and evaluating interactive systems, and designing and testing visualization techniques. His work draws on approaches from human-computer interaction, information visualization, and statistics to build information visualizations that people can more easily understand along with the models to back those visualizations.
Anna Kratz, PhD, is Assistant Professor of Physical Medicine and Rehabilitation and the Center for Clinical Outcomes Development and Application (CODA) at the University of Michigan, Ann Arbor.
Dr. Kratz’s clinical research is focused on the characteristics and mechanisms of common symptoms (e.g. pain, fatigue, cognitive dysfunction) and functional outcomes in those with chronic clinical conditions. Using a combination of ambulatory measurement methods of physical activity (actigraphy), heart rate variability, galvanic skin response, and self-reported experiences, her research aims to overlay the patient’s day-to-day experience with physiological markers of stress, sleep quality, and physical activity. She utilizes a number of computational approaches, including multilevel statistical modeling, signal processing, and machine learning to analyze these data. The ultimate goal is to use insights from these data to design better clinical interventions to help patients better manage symptoms and optimize functioning and quality of life.
Dr. Suzuki is a behavioral scientist and has major research interests in examining and intervening mediational social determinants factors of health behaviors and health outcomes across lifespan. She analyzes the National Health Interview Survey, Medical Expenditure Panel Survey, National Health and Nutrition Examination Survey as well as the Flint regional medical records to understand the factors associating with poor health outcomes among people with disabilities including children and aging.