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Geoff Ginsburg, MD, PhD, Duke University – MIDAS Seminar Series
September 9, 2016 @ 4:00 pm - 5:00 pm
Geoff S. Ginsburg, MD, PhD
Professor of Medicine, Pathology, and Biomedical Engineering
Director, Duke Center for Applied Genomics & Precision Medicine
Director, Duke MEDx
“Novel Genomic Paradigms for Early Detection and Diagnosis of Acute Infectious Disease”
Abstract: Early detection of infection could have profound implications on patient management and prognosis by allowing prompt initiation of appropriate therapy. This strategy is not possible with current culture-based diagnostic platforms owing to their low sensitivities and the time required to obtain results. Compelling evidence now exists that the host response to pathogens, in the form of pathogen-specific host gene and protein expression signatures, can serve as a potential early and rapid diagnostic strategy. Therefore we have identified host gene expression profiles as a strategy for the diagnosis of infection. Using unbiased sparse latent factor regression analysis, we generated gene signatures (or factors) from peripheral blood RNA analysis that distinguish individuals with symptomatic acute viral respiratory infection from individuals with bacterial infection or from uninfected individuals with ~ 90% accuracy. Signatures specific for bacterial infection and for non-infectious illness based on the host response have also been derived allowing for the distinction of viral and bacterial infection. Moreover, through a series of partnerships we have developed prototype novel sensing technologies for mRNA that can elevate this approach from a research-based endeavor to a clinically useful point of care diagnostic tool. Host-based diagnostics using novel nucleic acid and protein detection technologies will result in a paradigm shift in the early detection and diagnosis of infectious disease.
Bio: Dr. Ginsburg is the founding director for the Center for Applied Genomics & Precision Medicine at the Duke University Medical Center and for MEDx, a partnership between the Schools of Medicine and Engineering to spark and translate innovation. His research addresses the challenges for translating genomic information into medical practice and the integration of precision medicine into healthcare. He serves as a member of the Board of External Experts for the NHLBI, of the advisory council for the National Center for Accelerating Translational Science, and of the World Economics Forum’s Global Agenda Council on the Future of the Health Sector. He is co-Chair of the Institute of Medicine’s Roundtable on Genomics and Precision Health, of the Cures Acceleration Network, and of IOM/NIH Global Genomic Medicine Collaborative.
For more information on MIDAS or the Seminar Series, please contact firstname.lastname@example.org. MIDAS gratefully acknowledges Northrop Grumman Corporation for its generous support of the MIDAS Seminar Series.
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