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Biostatistics Seminar: Charles Kooperberg, PhD
October 22, 2015 @ 3:30 pm - 5:00 pm
Title: Quantification of Multiple Tumore Clones Using Gene Array and Sequencing Data Abstract: Copy number aberrations are important drivers of cancer development. The detection of such aberration in tumor cells is often complicated by possible contamination of normal cells and intratumor heterogeneity, for example the presence of multiple clones of tumor cells. In order to correctly quantify copy number aberrations, it is critical to de-convolute the complex structure of the genetic information from tumor samples. We propose a method for estimating copy number aberrations when there is potentially more than one major tumor clone as well as normal cells. We incorporate prior information on the distribution of the copy numbers to prioritize biologically more plausible solutions and alleviate possible identifiability issues that have been observed by many researchers. Our model is flexible and can work for both SNP array and sequencing data. We illustrate our approach on multiple datasets. This is joint work with Yichen Cheng and James Dai. Bio: Charles Kooperberg, Ph.D. Biostatistics and Biomathematics Program Head, Fred Hutchinson Cancer Research Center Affiliate Professor of Biostatistics, University of Washington